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Carbonic anhydrase. --- Carbonic Anhydrases --- chemistry. --- pharmacokinetics. --- Carbonate dehydratase --- Lyases --- Zinc enzymes

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Carbonic anhydrases (CAs, EC 4.2.1.1) are ubiquitous metalloenzymes, present throughout most living organisms and encoded by five evolutionarily unrelated gene families. The Carbonic Anhydrases as Biocatalysts: From Theory to Medical and Industrial Applications presents information on the growing interest in the study of this enzyme family and their applications to both medicine and biotechnology. Offers comprehensive coverage of the carbonic anhydrases enzyme family and their properties as biocatalystsIncludes current applications of carbonic anhydrases in biotechnology on the basis of their

Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- Carbonic anhydrase. --- Carbonic anhydrase --- Enzymes. --- Enzymes --- Biotechnology. --- Therapeutic use. --- Chemical engineering --- Genetic engineering --- Biocatalysts --- Ferments --- Soluble ferments --- Catalysts --- Proteins --- Enzymology --- Carbonate dehydratase --- Lyases --- Zinc enzymes

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  The study of carbonic anhydrase has spanned multiple generations of scientists.  Carbonic anhydrase was first discovered in 1932 by Meldrum and Roughton.  Inhibition by sulfanilamide was shown in 1940 by Mann and Keilin.  Even Hans Krebs contributed to early studies with a paper in 1948 showing the relationship of 25 different sulfonamides to CA inhibition. It was he who pointed out the importance of both the charged and uncharged character of these compounds for physiological experiments.             The field of study that focuses on carbonic anhydrase (CA) has exploded in recent years with the identification of new families and isoforms.  The CAs are metalloenzymes which are comprised of 5 structurally different families: the alpha, beta, gamma, and delta, and epsilon classes.  The alpha class is found primarily in animals with several isoforms  associated with human disease.  The beta CAs are expressed primarily in plants and are the most divergent.  The gamma CAs are the most ancient. These are structurally related to the beta CAs, but have a mechanism more similar to the alpha CAs.   The delta CAs are found in marine algae and diflagellates.  The epsilon class is found in prokaryotes in which it is part of the carboxysome shell perhaps supplying RuBisCO with CO2 for carbon fixation.               With the excitement surrounding the discovery of disease-related CAs, scientists have redoubled their efforts to better understand structure-function relationships, to design high affinity, isotype-specific inhibitors, and to delineate signaling systems that play regulatory roles over expression and activity.  We have designed the book to cover basic information of mechanism, structure, and function of the CA families.  The authors included in this book bring to light the newest data with regard to the role of CA in physiology and pathology, across phylums, and in unique environmental niches.

Carbonic anhydrase. --- Lyases. --- Desmolases --- Carbonate dehydratase --- Medicine. --- Medical genetics. --- Proteins. --- Biomedicine. --- Gene Function. --- Protein Science. --- Biomedicine general. --- Enzymes --- Lyases --- Zinc enzymes --- Biochemistry. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Clinical genetics --- Diseases --- Heredity of disease --- Human genetics --- Genetic disorders --- Composition --- Genetic aspects --- Health Workforce --- Proteins . --- Biomedicine, general. --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Medicine --- Medical Genetics. --- Protein Biochemistry. --- Biomedical Research. --- Research. --- Biological research --- Biomedical research

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DNA-Directed DNA Polymerase --- DNA-Directed RNA Polymerases --- Enzyme Inhibitors. --- Antibiotics --- -DNA polymerases --- -RNA polymerases --- -DNA-dependent RNA polymerases --- DNA-directed RNA polymerases --- Polymerases, RNA --- Ribonucleate nucleotidyltransferases --- RNA nucleotidyltransferases --- Transferases --- Deoxyribonucleate nucleotidyltransferases --- DNA-dependent DNA polymerases --- DNA-directed DNA polymerases --- DNA nucleotidyltransferases --- Nucleotidyltransferases, Deoxyribonucleate --- Polymerases, DNA --- Zinc enzymes --- Polymerase chain reaction --- Anti-infective agents --- Microbial metabolites --- Allelopathic agents --- Antibiosis --- Pharmaceutical microbiology --- Phytoncides --- Inhibitors, Enzyme --- Enzymes --- Sulfhydryl Reagents --- antagonists & inhibitors. --- Physiological effect --- -Congresses --- Inhibitors --- antagonists & inhibitors --- -antagonists & inhibitors. --- DNA polymerases --- RNA polymerases --- Congresses. --- Enzyme Inhibitors --- DNA-dependent RNA polymerases --- Physiological effect&delete& --- Congresses --- Inhibitors&delete& --- Enzyme Inhibitor --- Inhibitor, Enzyme --- DNA Polymerase Inhibitors --- Inhibitors, DNA Synthesis --- Inhibitors, Nucleic Acid Synthesis --- Inhibitors, RNA Synthesis --- DNA Polymerase Inhibitor --- DNA Synthesis Inhibitor --- DNA Synthesis Inhibitors --- Nucleic Acid Synthesis Inhibitor --- RNA Synthesis Inhibitor --- RNA Synthesis Inhibitors --- Inhibitor, DNA Polymerase --- Inhibitor, DNA Synthesis --- Inhibitor, RNA Synthesis --- Inhibitors, DNA Polymerase --- Polymerase Inhibitor, DNA --- Polymerase Inhibitors, DNA --- Synthesis Inhibitor, DNA --- Synthesis Inhibitor, RNA --- Synthesis Inhibitors, DNA --- Synthesis Inhibitors, RNA --- DNA --- RNA --- ENZYME INHIBITORS --- CHEMICAL SYNTHESIS